Latest research.
A closer look at everyday life.

Authors: Zuzanna Gurzyńska, Karolina Kucka, Marcin Trzciński, Katarzyna Topolska, Katarzyna Nowicka-Sauer, Krzysztof Sobczak

The period of university studies is associated with numerous stressors that can negatively affect the psychological functioning of young adults. This study aimed to investigate the relationship between perceived stress levels, preferred coping strategies, and psychological resilience. The analysis focused on resilience as a potential moderator of the relationship between coping strategies and stress intensity. The study included 607 Polish students. A significant part of the group was medical students (61.72%). The study employed the Perceived Stress Scale (PSS-10), the Coping Inventory (Mini-COPE), the Resilience Scale (SPP-25), and used an author-developed questionnaire to collect sociodemographic information. The respondents exhibited moderate stress intensity (M = 22.54; SD = 7.04) and a moderately high level of general resilience (M = 59.39; SD = 15.37). Among coping strategies, acceptance (M = 1.94) and active coping (M = 1.85) were chosen most frequently, while turning to religion and helplessness were chosen least frequently. Analysis of personal resources showed the highest scores in openness to experience and sense of humor. Interaction effects rarely reached statistical significance. The study group showed a profile of students who were stressed but had functional coping resources. The moderation analysis results indicate the complex nature of the relationships among the variables studied—although psychological resilience is a key resource, its role as a moderator of the relationship between coping strategies and stress is not universal and emerges only in specific areas of functioning. The data obtained suggest that psychological interventions should focus on strengthening existing resources (such as active coping) and developing resilience, which may serve as a buffer against the negative effects of academic stress.

Source: PLOS ONE. DOI: 10.1371/journal.pone.0360002. Abstract from the publisher’s feed; HTML formatting and repeated author line removed.

Authors: Siavash Shirzadeh Barough, Behnam Saeidi, Fateme Binayi, Mina Salimi, Fatemeh Siavoshi, Roxana Karbaschi, Mehdi Hedayati, Homeira Zardooz

Early life stress (ELS) significantly contributes to metabolic and psychological disorders by triggering oxidative stress and disrupting the hypothalamic–pituitary–adrenal (HPA) axis. This research examined ELS effects on redox status, along with anxiety-like behavior, in adolescent male Wistar rats, also assessing saffron (Crocus sativus L.) extract’s potential benefits. Rats were exposed to foot shock stress from postnatal days 15–19, with treatment groups receiving saline or saffron extract (10 mg/kg) via intraperitoneal injection. Control groups were maintained without stress exposure. Elevated Plus Maze (EPM) and Open Field Test (OFT) were used to evaluate anxiety-like behaviors. Corticosterone, glucose, and insulin levels, oxidative stress markers [malondialdehyde (MDA), glutathione (GSH), and catalase activity] in the plasma, pancreas, and amygdala were determined, and the HOMA-β index was estimated. Saffron extract markedly restored ELS effects by reducing fasting plasma glucose and corticosterone levels, while increasing insulin levels and the HOMA-β index in adolescent offspring. Additionally, saffron extract inhibited oxidative stress, evidenced by reduced MDA, normalized catalase activity, and augmented GSH levels in the plasma, pancreas, and amygdala. Behaviorally, saffron extract-treated rats exhibited diminished anxiety-like behaviors, characterized by increased time spent in the open arms of the EPM and the center zone in the OFT. This study suggests that ELS induces disturbances in glucose metabolism and anxiety-like behavior, accompanied by oxidative stress and increased HPA axis activity. The protective role of saffron extract underscores its capability to serve as a medicinal compound for preventing and treating stress-induced metabolic and anxiety disorders.

Source: PLOS ONE. DOI: 10.1371/journal.pone.0359395. Abstract from the publisher’s feed; HTML formatting and repeated author line removed.

Authors: Joyce Aputere Ndago, Paul Adjorlolo, Martin Nyaaba Adokiya, Micheal Boah

Access to and use of improved water sources and sanitation facilities in Sub-Saharan Africa (SSA) remains a significant public health concern, with notable variations across countries. Achieving the Sustainable Development Goals related to water and sanitation require evidence on current levels of access and factors that shape them. This study examined household access to and use of improved water sources and sanitation facilities, as well as the determinants of their use in SSA. Demographic and Health Survey data from 465,208 households across 30 SSA countries conducted between 2014 and 2025 was used for this study. Descriptive analyses examined access levels. Multivariable Poisson regression with robust variance was used to identify the factors associated with reported use. Overall, 76.3% of households had access to and use of improved water sources, 56.7% had access to improved toilets, and 35.4% had access to basic sanitation facilities (unshared improved toilet facilities), with wide variations across countries. Significant factors associated with access and use of improved toilet and sanitation facilities included wealth and residence, while educational attainment was significantly associated with access to and use of improved water sources. The findings highlight that disparities in access to water and sanitation exist in the SSA region, with household wealth, place of residence, and education significantly associated with households’ access and use of improved water sources and sanitation facilities. Governments in SSA should prioritize improving access to water and sanitation, particularly in underserved areas. Additionally, targeted strategies are needed to address disparities driven by socioeconomic and demographic factors.

Source: PLOS Global Public Health. DOI: 10.1371/journal.pgph.0006195. Abstract from the publisher’s feed; HTML formatting and repeated author line removed.

Authors: Nikita Surani, Nathalia Carolina Fernandes Fagundes, Harmanpreet Kaur, Rebecca Gokiert, Arnaldo Perez-Garcia, Maryam Amin

Children experience significant oral health problems, compromising learning and quality of life. Schools are effective in promoting children’s overall health, within which oral health can be integrated. This scoping review aimed to map integration of oral health within primary school health programs. The review was guided by Arksey and O’Malley’s framework and adhered to Preferred Reporting Items for Systematic reviews and Meta-Analyses extensions for Scoping Reviews (PRISMA-ScR). JBI Manual for Evidence Synthesis was referred to for data extraction. A systematic search was performed across six databases with no restrictions on dates and locations. The review included 31 articles published between 1981 and 2025. Over 70% studies were concentrated exclusively in high-income and upper-middle income regions. Quantitative methods were reported in twenty-one studies. All studies reported programs targeting children. Only 12 included parents or guardians, mostly as passive recipients. Most common intervention delivery agents were teachers, identified in 25 studies. Unhealthy diet and poor hygiene were frequently targeted common risk factors, identified in 18 and 11 studies respectively. Tobacco use, stress, and injury were largely overlooked. Twenty-seven studies reported activity-based learning to promote general health. Classroom education, followed by interest holder engagement and structured toothbrushing were used to promote oral health, focusing on student skill-building and empowerment, alongside teacher involvement. None of the studies applied integration-specific or implementation science frameworks or models. Twenty-six studies assessed child-level oral health outcomes. In contrast, only seven reported changes in knowledge, attitudes, and practices among educators and parents. Ten reported program-related outcomes. Structured programs engaging children, targeting risk factors related to hygiene and diet alongside interest holder engagement and curriculum integration hold promise. This review highlights the need for theoretically informed, comprehensive, policy-focused, multi-level, multi-risk factor approaches to support sustainable integration of oral health into school health programs.

Source: PLOS Global Public Health. DOI: 10.1371/journal.pgph.0007390. Abstract from the publisher’s feed; HTML formatting and repeated author line removed.

Authors: Basil H. Aboul-Enein, Suha Ballout, Patricia J. Kelly

Maternal mental health (MMH) remains a critical public health issue across Sub-Saharan Africa (SSA). Despite the high burden, access to culturally appropriate and evidence-based mental health interventions remains limited. This scoping review examines interventions targeting mental health outcomes for pregnant and postpartum women across SSA countries. Guided by PRISMA-ScR and Arksey and O’Malley’s framework, a comprehensive search was conducted across 14 electronic databases for peer-reviewed intervention studies published in English between 2000 and March 2026. A total of 57 studies across 18 SSA countries were identified with interventions primarily focused on the individual or mother-infant level. The majority used strong research methods, with widely varying intervention content, including cognitive-behavioral therapy, problem-solving therapy, psychoeducation, and community-based programs, often delivered by community health workers, focusing on problem-solving skills, and involving cash transfers. While most studies reported reductions in depressive symptoms and improved psychosocial outcomes, few addressed scalability, health system integration, or cost-effectiveness. Few studies worked with health professionals or included technology interventions. A wide range of mental health interventions show promise in addressing perinatal mental health in SSA. However, gaps remain in scaling up sustainable, culturally relevant, and system-integrated interventions. Future efforts should prioritize provider education, health system strengthening, and evaluation of economic impact to enhance MMH outcomes across the region. To have a significant impact on perinatal mental health, future interventions that focus on cost-effectiveness, scalability, health professions education, and integration of technology are needed.

Source: PLOS Mental Health. DOI: 10.1371/journal.pmen.0000739. Abstract from the publisher’s feed; HTML formatting and repeated author line removed.

Authors: Nicholas Yee Liang Hing, Yew Kong Lee, Hyung Joon Kim, Nurhyikmah M. Lothfi, Elizabeth Wong, Joan Costa-Font

The COVID-19 infodemic highlighted the need to identify the extent to which health information messengers were perceived as reliable by the public in supporting effective public health communication. A question that remains is whether there are differences across ethnic groups in information processing. This study examines the perceived reliability of three formal sources (healthcare workers, scientists, and non-governmental organisations [NGOs]) and four informal sources (religious leaders, community leaders, interpersonal sources, and influencers) among Malaysia’s multi-ethnic population through a cross-sectional online survey conducted between April and June 2021. Logistic regression was used to identify the perceived reliability of different information sources in steering vaccination intentions. We further examine the extent to which there were ethnic differences in the perceived reliability of these sources across education levels and age groups. Adjusted predicted probabilities were estimated to illustrate these differences. Among 5,784 participants, formal sources were consistently perceived as the most reliable across all ethnic groups and, together with community leaders, were identified as the main information sources influencing vaccination intention. We find large predicted probabilities of perceiving healthcare workers and scientists as reliable across most groups (≥ 80%), except among Indigenous groups who exhibit lower education attainment and are older (≤ 78%). Across education levels and age groups, Indians and Chinese exhibit higher predicted probabilities of perceiving NGOs as reliable, averaging approximately 80% and 75%, respectively, compared with approximately 65–70% among Malays and Indigenous groups. In contrast, predicted probabilities of perceiving community leaders as reliable were moderate across all ethnicities at the lowest education level and youngest age group (45 – 55%). This pattern remained relatively stable across higher education levels and age groups among Malays and Indigenous groups, but generally decreased among Chinese and Indian respondents. These results suggest that healthcare workers and scientists ought to remain central to health communication strategies, while NGOs and community leaders may play complementary roles. Multi-messenger approaches may enhance the effectiveness of public health responses during health crises.

Source: PLOS Global Public Health. DOI: 10.1371/journal.pgph.0007397. Abstract from the publisher’s feed; HTML formatting and repeated author line removed.

Authors: Pooja Yerramilli, Mickey Chopra

Global health is facing unprecedented upheaval, with significant donor disruptions requiring a reconfiguration of the global health landscape. While recently proposed frameworks for the next phase of global health represent meaningful progress in grappling with this context, their central weakness is not technical but normative. In this Essay, we argue that if the new global health architecture is defined without meaningful interrogation of its central purpose, then the system will reproduce the very problems it aims to solve. On the other hand, explicitly centering health equity as the organizing principle of the new “global health” brings to the foreground the shared struggles and movements of marginalized communities worldwide. In doing so, it demands a more fundamental, global reckoning with the structural determinants – politics and power - that produce ill health across and within countries. From this logic flows substantive shifts in global health functions, predicated on a social-ecological model: from substitution to mutual aid; from technical assistance to knowledge sharing; from global public goods to multisectoral common goods for all; and from mechanisms that facilitate global coordination to ones that also critically address the distribution of power and resources.

Source: PLOS Global Public Health. DOI: 10.1371/journal.pgph.0007379. Abstract from the publisher’s feed; HTML formatting and repeated author line removed.

Authors: Lauren D’Mello-Guyett, Neelina Jaggarwal, Jane Wilbur, Belen Torondel, Meghna Ranganathan

Menstrual health and hygiene (MHH) encompasses access to menstrual materials; water, sanitation, and disposal facilities; privacy and safety; accurate information; supportive social environments; access to care for menstrual discomfort and disorders; enabling people to manage menstruation with dignity and choice. Climate change is disrupting these interlinked domains, disproportionately affecting women, girls, and people who menstruate. This review synthesises evidence on how climate change affects MHH across diverse climate hazard contexts. We conducted a global mixed-methods systematic review of studies published in English between 1947 and 2025, examining associations between climate-related hazards and MHH. We conducted searches in Medline, Scopus, Embase, and Web of Science. Quantitative, qualitative, and mixed-methods studies were eligible. Given the heterogeneity in exposures, outcomes, and designs, findings were synthesised narratively. From 3,890 records, 25 studies met inclusion criteria, covering floods (n = 7), air pollution (n = 6), cyclones (n = 3), droughts (n = 3), saltwater intrusion (n = 3), and multiple hazards (n = 4). Flood- and cyclone-related studies reported disrupted access to menstrual materials, damaged water and sanitation infrastructure, reduced privacy and safety, limited access to care for menstrual disorders, and unsupportive social environments characterised by stigma and restricted mobility. Drought and salinity intrusion constrained hygiene practices through reduced water availability and quality, affecting comfort, dignity, and infection risk. Across hazards, studies documented adverse physical outcomes, including dermatological irritation and reproductive or urinary tract infections, alongside psychosocial consequences such as shame, anxiety, and harassment. Air pollution studies linked exposures with earlier menarche and menstrual cycle irregularities. Evidence on extreme heat and several MHH domains, including access to information, was limited. Climate-related hazards undermine multiple, interconnected domains of MHH. The evidence base remains fragmented across hazards, geographies, methods, underscoring the need to integrate MHH into climate adaptation, disaster preparedness, and humanitarian response frameworks and to address critical research gaps related to extreme heat, slow-onset hazards, and equity.

Source: PLOS Climate. DOI: 10.1371/journal.pclm.0001083. Abstract from the publisher’s feed; HTML formatting and repeated author line removed.

Authors: Emmanuel Oloche Otukpa, Abdhalah K. Ziraba, Luchuo Engelbert Bain

Co-creation is widely advocated in global health research and inconsistently practiced. This paper offers a reflective, practice-based synthesis of two decades of co-created research, policy engagement and advocacy at the African Population and Health Research Center (APHRC).We define co-creation through four dimensions; shared agenda setting, joint knowledge production, power sharing, and community leadership and ownership. We distinguish it from consultation, stakeholder engagement and partnership, and assess each dimension on a graded scale. To this we add a second axis: the reach of co-creation across the research-to-policy-to-advocacy interface, and the condition of the transitions between its segments. Six cases spanning evidence generation, policy processes, capacity strengthening and rights-based advocacy are assessed against both axes. Three findings emerge. Co-creation in this institution’s practice is substantive where knowledge is produced and weak where authority is held. Agendas were substantively shared in four of six cases and financial resources in none. It fails at the transitions between research, policy engagement and advocacy rather than within them, at moments that were neither designed nor evaluated nor recorded. And the domains of co-creation differ systematically in the dimensions they can realize, with community leadership substantive only in rights-based advocacy. We draw practice guidance on governance, funding, community roles, transitions and assessment, and state what a single-institution insider synthesis cannot establish.

Source: PLOS Global Public Health. DOI: 10.1371/journal.pgph.0007405. Abstract from the publisher’s feed; HTML formatting and repeated author line removed.

Authors: Webster Mavhu, Jermaine M. Dambi, Victoria Simms, Faith Martin, Joni Lariat, Rufaro Mbundure, Leviticus Makoni, Laura Kafata, Carol Wogrin, Vivian Chitiyo, Abigail Mutsinze, Frances M. Cowan, Nicola Willis, Sarah Bernays

Adolescents living with HIV (ALHIV) in Eastern and Southern Africa experience challenges around medication adherence, mental health and wellbeing. Although interventions such as Zvandiri aim to strengthen mental health and wellbeing to impact HIV treatment outcomes, available measures often focus on negative outcomes or rely on positive psychology instruments developed in high-income settings. These tools may not adequately capture culturally embedded and relational dimensions of wellbeing. We describe the development of the Zvandiri Character Strength (ZCS) scale and draw methodological lessons for culturally grounded wellbeing measurement. The multi-stage scale-development process (2022–2025) comprised a scoping and systematic review, qualitative discussions, expert panel input, construct and item prioritisation, cognitive interviews, iterative item reduction, and exploratory factor and Rasch analyses. We reduced an initial item bank to a 53-item candidate scale, then to the ZCS 38 (38 items) and finally, the ZCS 25 (25 items), based on quantitative analyses and participant feedback. We subsequently assessed the ZCS 25 using retrospective pretest, post-test and follow-up administration. The review identified conceptually overlapping positive psychological constructs, many of which are measured using instruments developed in high-income settings and not adequately validated for ALHIV in Africa. Qualitative work highlighted connectedness, hope, self-acceptance, self-efficacy, purpose, and flourishing as key. Discussions also highlighted that wellbeing was relational, contextually situated, and often co-occurring with distress. Quantitative testing showed highly positive responses, disordered thresholds, ceiling effects, weak internal structure, and fluctuating retrospective ratings. Participant feedback suggested that positive responses likely reflected affirmations, and were partly linked to social desirability. In conclusion, the ZCS scale did not support a single interpretable total score, but its development offers important methodological lessons. Future measurement should begin with clearer construct definition, response-process validation, domain-level testing and explicit decisions about whether the measure aims to capture lived wellbeing, domain-specific positive outcomes or intervention-relevant change.

Source: PLOS Global Public Health. DOI: 10.1371/journal.pgph.0006845. Abstract from the publisher’s feed; HTML formatting and repeated author line removed.